Endocrine Abstracts

Objective: To describe the phenotypic and molecular characteristics of familial thyroid dyshormonogenesis (FTDH) in the Tunisian population.Patients and Methods: A retrospective descriptive study including two related (R and K) with high consanguinity whose members are carriers of FTDH. Biological and genetic screening was proposed for all consenting members.Results: FTDH was identified in 11 patients (8 girls, 3 boys) with a mean ...

Introduction: Even at physiological doses, glucocorticoid replacement therapy may lead to deleterious outcomes on bone mineral density (BMD).The aim of our study was to investigate the BMD in Tunisian patients with Addison disease and to identify the risk factors associated with its decline.Patients and methods: The study included 50 patients diagnosed with primary adrenal disease (Addison disease). BMD was assessed by the dual -energy -X-ray absopitomet...

Introduction: Distal and symmetrical peripheral polyneuropathy is the most frequent type of diabetic neuropathy. Its painful form (PDN) is the most common cause of non-traumatic neuropathic pain and can place a heavy burden on patients’ lives. Despite the major impact that it can have on the quality of life, PDN is generally underdiagnosed because of a large interindividual variability of symptoms and in the absence of well-established diagnostic criteria.<p class="ab...

Background and Aims: Lower urinary tract (LUT) dysfunctions are highly prevalent, especially in women. Diabetes is a well-established risk factor for developing LUT symptoms. Several studies suggest that a high body mass index (BMI) may worsen the urinary discomfort in patients with type 2 diabetes (T2DM). The current survey aims to investigate the relationship between obesity and LUT dysfunctions in patients with T2DM.Patients and Method: We conducted a...

Background and Aims: Several studies have pointed a significant relationship between diabetic complications, glycemic imbalance, and the onset of lower urinary tract dysfunction (LUTD) in this population. The current survey aims to assess the clinical and biochemical characteristics related to glycemic control in patients with type 2 diabetes presenting with symptoms of LUTD.Patients and Method: We conducted a comparative cross-sectional study that inclu...

Introduction: Hyperuricemia is a common metabolic feature in patients with metabolic syndrome.Aim: The aim of our work is to study the correlation between uric acid level and the metabolic profile in hypertensive type 2 diabetic patients.Methods: This is a retrospective descriptive study of hypertensive type 2 diabetic patients followed in the endocrinology department of Hedi Chaker University Hospital of Sfax, Tunisia between 2019...

Background: Poor glycemic control in patients with diabetes mellitus(DM) is a well-documented responsible factor for microvascular complications, especially eye and kidney damage. The onset of chronic kidney disease(CKD) marks a serious turning point in the clinical history of DM in terms of cardiovascular prognosis. Our study aims to assess the cardiovascular risk(CVR) in diabetic patients with CKD.Method: We conducted a retrospective descriptive study ...

Introduction and aim: Diabetic foot (DF) is associated with increased morbimortality and cost of diabetes management. The aim of this study is to describe the epidemiological, clinical and paraclinical characteristics and follow-up outcomes of patients with diabetic foot in a Tunisian center.Methods: It is a monocentric retrospective study of 210 patients with diabetic foot followed at the endocrinology department of the Hedi Chaker Sfax University Hospi...

Introduction: Berberis vulgaris is a plant, of the family Berberidaceae. Berberine is the main active compound of the barberry. It is an iso quinoline alkaloid of intense yellow color. Berberis vulgaris is used in several medical purposes, including liver protection, anti-oxidant, antimicrobial agent. It also seems to reduce the level of cholesterol in the blood and triglycerides. Our study aims to investigate the effect of the dietary supplement "Berberis Vulgaris" ma...

Introduction: Pancreatic cancer is one of the digestive system cancers whose prognosis has not been improved, both in terms of early diagnosis and prognosis, despite the progress in clinical, radiological and biological investigation. A significant number of patients present at the time of diagnosis of this cancer, or just before, a relatively recent onset diabetes. The link between diabetes and pancreatic cancer is established, but it is sometimes difficult to distinguish whe...